WebFeb 4, 2024 · Tumor suppressor SMARCA4 (BRG1), a key SWI/SNF chromatin remodeling gene, is frequently inactivated in cancers and is not directly druggable. We recently uncovered that SMARCA4 loss in an... WebNov 2, 2024 · AbstractPurpose:. SMARCA4 mutations are among the most common recurrent alterations in non–small cell lung cancer (NSCLC), but the relationship to other genomic abnormalities and clinical impact has not been established.Experimental Design:. To characterize SMARCA4 alterations in NSCLC, we analyzed the genomic, protein …
SMARCA4-deficient lung carcinoma is an aggressive tumor highly …
WebSMARCA4 deficient (d) NSCLC is an aggressive subtype of primary lung adenocarcinoma that is often confused with metastatic disease to the lung. Methods. Results. SMARCA4d was inactivated by short variant base substitutions and truncations (88%), deletions (9%), duplications (1%), rearrangement/fusions (1%). SMARCA4d patients were slightly ... WebSMARCA4 knockdown in human mammary epithelial MCF-10A cells resulted in 176 up-regulated genes, including many related to lipid and calcium metabolism, and 1292 down-regulated genes, some of which encode extracellular matrix (ECM) components that can exert mechanical forces and affect nuclear structure. green transport policy template
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WebMar 29, 2024 · Rekhtman N. Lung neuroendocrine neoplasms: recent progress and persistent challenges. Mod Pathol. 2024 Jan;35(Suppl 1):36-50. doi: 10.1038/s41379-021-00943-2. Epub 2024 Oct 18. WebDec 3, 2024 · SMARCA4 is a tumor suppressor that is aberrant in ∼5% to 7% of human malignancies. Class I SMARCA4 alterations (truncating mutations, fusions, and homozygous deletion) lead to loss of function whereas class II alterations (missense mutations) have a dominant negative/gain-of-function effect and/or loss-of function. WebNov 3, 2024 · a SMARCA4 alteration frequency separated by disease ontology ( n = 131,668 patients). b Distribution of SMARCA4 mutation types ( n = 10,562 variants). c Zygosity of SMARCA4 truncating and... green transport in south africa